N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
- Product Name
- N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
- CAS No.
- 249889-64-3
- Chemical Name
- N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA
- Synonyms
- CS-1473;SB 334867;SB 334867A;Zinc00008794;SB334867 HCl;SB-334867 hydrochloride;SB 334867 hydrochloride NEW;SB 334867A; SB334867; SB 334867;N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-, (Hydrochloride)
- CBNumber
- CB1458943
- Molecular Formula
- C17H13N5O2
- Formula Weight
- 319.32
- MOL File
- 249889-64-3.mol
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Property
- Melting point:
- >235°C (dec.)
- storage temp.
- Desiccate at RT
- solubility
- Dichloromethane (Slightly), DMSO (Slightly)
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 1960
- Product name
- SB334867
- Purity
- ≥99%(HPLC)
- Packaging
- 1
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 1960
- Product name
- SB334867
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 1960
- Product name
- SB334867
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $852
- Updated
- 2021/12/16
- Product number
- S154655
- Product name
- SB334867
- Packaging
- 100mg
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- API0008815
- Product name
- N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1381.33
- Updated
- 2021/12/16
N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production
Uses
SB 334867 is an orexin-1-receptor antagonist. An important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability.
Definition
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.
Biological Activity
Selective non-peptide orexin OX 1 receptor antagonist. pK b values are 7.2 and < 5 for inhibition of intracellular Ca 2+ release in CHO cells expressing human OX 1 and OX 2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo .
References
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.